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  1. #1
    DANGER low CARB Avatar de Garcia from HELL
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    Padrão Dose diaria de 25mg de CLOMID dobra os niveis de testosterona em homens

    Daily dose 25 mg Clomid doubles men's T levels
    A modest dose of the fertility drugClomid can help men with low testosterone levels and low sex drive. Researchers at the Centro de Andrologia e Urologia in Porto Alegre, Brazil came to this conclusion after studying 125 hypogonadal men.
    The participants in the Brazilian study had a testosterone level of 300-400 nanograms per decilitre. Their levels were within the limits of what doctors regard as normal – 200-1200 nanograms per decilitre – but they were on the low side. The men complained of lack of libido.Progressive doctors have been known to prescribe testosterone products for these complaints. They are effective in the short term, but may have long-term side effects such as "skin irritation, gynecomastia, nipple tenderness, testicular atrophy and decline in sperm counts", according to the researchers.
    Clomid – active ingredient clomiphene citrate – has none of these side effects. It is an anti-oestrogen that makes the brain think that there is too little steroid hormone circulating in the blood. As a result higher levels of steering hormones are produced, which stimulate testosterone production in the testes.
    Clomid not only has fewer side effects than testosterone, but it's also cheaper. Researchers at Rush University in the US calculated in 2010 that the costs of Clomid treatment are less than a third of treatments using testosterone preparations. [J Sex Med. 2010 Jan; 7(1 Pt 1): 269-76.]
    Because they wanted to see for themselves whether Clomid works in men, the Brazilians gave their test subjects a pill containing 25 mg clomiphene citrate every day for 3-6 months. The men's testosterone levels almost doubled, as you can see below.
    One side effect of testosterone therapy that is cause for concern among cardiologists is a worsening in the cholesterol balance, which is associated with an increased risk of cardiovascular problems. In this study there was no sign of this happening. In fact the Clomid actually improved the men's cholesterol levels a little.











    The treatment also reduced the sexual problems that most of the men had. Among the over-seventies however Clomid led to improvements in about half of the subjects, but no change was noticed in the other half.
    "Our data showed that a daily dose of 25 mg clomiphene citrate was effective in stimulating endogenous T production in a short follow-up", the Brazilians conclude. "No serious adverse events were recorded during the study period. This medication should be considered a therapeutic option for patients with symptomatic male testosterone deficiency."
    Source:
    Int Braz J Urol. 2012 Jul;38(4):512-8.
    compre no iHERB.COM e use o codigo de desconto ABU346, compras acima de 40USD ganham 10% de desconto.. and help a brother out ;)

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  4. #2
    INICIANTE Avatar de CobradePrata
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    Padrão Re: Dose diaria de 25mg de CLOMID dobra os niveis de testosterona em homens

    foda q o tempo citado no estudo é de 3~6 meses.

    mas é interessante do mesmo jeito, talvez seja legal utilizar uma quantidade "regressiva", ao terminar o ciclo de testo exógena utilizar uma quantidade "maior" e ir diminuindo e utilizar durante uns 2~3 meses essa quantidade citada...

    E bacana que o estudo é nacional hein ;)

  5. #3
    DANGER low CARB Avatar de Garcia from HELL
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    Padrão Re: Dose diaria de 25mg de CLOMID dobra os niveis de testosterona em homens

    o estudo nao é sobre TPC, não obstante 5-6 meses é o tempo que um organismo demora para se recuperar completamente de um ciclo
    compre no iHERB.COM e use o codigo de desconto ABU346, compras acima de 40USD ganham 10% de desconto.. and help a brother out ;)

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  7. #4
    EXPERIENTE Avatar de rabelo
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    Padrão Re: Dose diaria de 25mg de CLOMID dobra os niveis de testosterona em homens

    Será que tem algum "colateral"?

  8. #5
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    Padrão Re: Dose diaria de 25mg de CLOMID dobra os niveis de testosterona em homens

    Citação Postado originalmente por rabelo Ver Post
    Será que tem algum "colateral"?
    "Our data showed that a daily dose of 25 mg clomiphene citrate was effective in stimulating endogenous T production in a short follow-up", the Brazilians conclude. "No serious adverse events were recorded during the study period. This medication should be considered a therapeutic option for patients with symptomatic male testosterone deficiency."

    Hehe, tudo leva a crer que nao. Quero ver quem vai ser o primeiro a testar. Eu aguardo os relatos ueahuaehae.

    Abracos!

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  10. #6
    DANGER low CARB Avatar de Garcia from HELL
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    Padrão Re: Dose diaria de 25mg de CLOMID dobra os niveis de testosterona em homens

    • Here's a study showing low-dose Clomid therapy (25mg ED) boosts testosterone by 250% in 4-6 weeks:

      Clomiphene citrate effects on testosterone/estrogen ratio in male hypogonadism, Shabsigh A, Kang Y, Shabsign R, Gonzalez M, Liberson G, Fisch H, Goluboff E., J Sex Med. 2005 Sep;2(5):716-21.

      AIM: Symptomatic late-onset hypogonadism is associated not only with a decline in serum testosterone, but also with a rise in serum estradiol. These endocrine changes negatively affect libido, sexual function, mood, behavior, lean body mass, and bone density. Currently, the most common treatment is exogenous testosterone therapy. This treatment can be associated with skin irritation, gynecomastia, nipple tenderness, testicular atrophy, and decline in sperm counts. In this study we investigated the efficacy of clomiphene citrate in the treatment of hypogonadism with the objectives of raising endogenous serum testosterone (T) and improving the testosterone/estrogen (T/E) ratio. METHODS: Our cohort consisted of 36 Caucasian men with hypogonadism defined as serum testosterone level less than 300 ng/dL. Each patient was treated with a daily dose of 25 mg clomiphene citrate and followed prospectively. Analysis of baseline and follow-up serum levels of testosterone and estradiol levels were performed.

      RESULTS: The mean age was 39 years, and the mean pretreatment testosterone and estrogen levels were 247.6 +/- 39.8 ng/dL and 32.3 +/- 10.9, respectively. By the first follow-up visit (4-6 weeks), the mean testosterone level rose to 610.0 +/- 178.6 ng/dL (P < 0.00001). Moreover, the T/E ratio improved from 8.7 to 14.2 (P < 0.001). There were no side effects reported by the patients.

      CONCLUSIONS: Low dose clomiphene citrate is effective in elevating serum testosterone levels and improving the testosterone/estradiol ratio in men with hypogonadism.This therapy represents an alternative to testosterone therapy by stimulating the endogenous androgen production pathway.

    • Study showing a hypogonadic 30-year old male, suffering permanent shutdown from steroid abuse, fully recovered natural hormone levels and HPTA function from 2 months of 100mg Clomid therapy:


      Use of clomiphene citrate to reverse premature andropause secondary to steroid abuse, Tan RS, Vasudevan D., Fertility and Sterility, Volume 79, Issue 1, Pages 203-205


      OBJECTIVE: To report a case of symptomatic hypogonadism induced by the abuse of multiple steroid preparations that was subsequently reversed by clomiphene. DESIGN: Case report. SETTING: University-affiliated andrology practice within family practice clinic. PATIENT(S): A 30-year-old male.

      INTERVENTION(S): Clomiphene citrate, 100-mg challenge for 5 days, followed by treatment at same dose for 2 months.

      MAIN OUTCOME MEASURE(S): Clinical symptoms, androgen decline in aging male questionnaire, total T, FSH, LH.

      RESULT(S): Reversal of symptoms, normalization of T levels with LH surge, restoration of pituitary-gonadal axis.

      CONCLUSION(S): Clomiphene citrate is used typically in helping to restore fertility in females. This represents the first case report of the successful use of clomiphene to restore T levels and the pituitary-gonadal axis in a male patient. The axis was previously shut off with multiple anabolic steroid abuse.
    • Here's another study showing only 7 days of Clomid therapy increased total testosterone by 100% and, more importantly, free testosterone by over 300% in young men:

      The effects of aging in normal men on bioavailable testosterone and luteinizing hormone secretion: response to clomiphene citrate, Bremner, William J, J Clin Endocrinol Metab. 1987 Dec;65(6):1118-26


      Serum testosterone (T) levels in men decline with age while serum LH levels, as measured by RIA, increase. To assess if the decline in serum T levels in healthy aging men is paralleled by an age-related decline in the bioavailable non-sex hormone-binding globulin (SHBG)-bound fraction of T and to determine whether there are age-related changes in LH secretion or LH control of T production, we studied 29 young (aged 22-35 yr) and 26 elderly (aged 65-84 yr) healthy men. All men had single random blood samples drawn, and 14 men in each age group underwent frequent blood sampling for 24 h, both before and after 7 days of clomiphene citrate (CC) administration. Both mean 24-h serum total T levels and non-SHBG-bound T were reduced in elderly men compared to those in young men (P less than 0.05), while estradiol and SHBG levels were similar in the 2 age groups. Serum FSH determined by RIA and LH by RIA and bioassay were higher in the elderly men compared to those in young men (P less than 0.05), but the ratios of LH bioactivity to immunoreactivity and the LH pulse frequency and amplitude were similar. After CC administration, mean serum total T and non-SHBG-bound levels in young men increased by 100% and 304%, respectively, while in older men these values increased by only 32% and 8%, respectively. However, CC-stimulated LH pulse characteristics and serum levels of estradiol, SHBG, FSH, and bioactive and immunoreactive LH were similar in the 2 groups. Thus, both at baseline and after CC stimulation, elderly men had significantly lower serum total T and non-SHBG-bound (bioavailable) T levels than did young men, despite similar or increased levels of bioactive LH and similar bioactive to immunoreactive LH ratios and LH pulse characteristics. These results suggest that major age-related changes in the hypothalamic-pituitary-testicular axis occur at the level of the testes and are manifested by decreased responsiveness to bioactive LH. Administration of CC to young and elderly men resulted in similar changes in LH pulse characteristics and LH bioactivity and immunoreactivity, suggesting preserved hypothalamic-pituitary responsiveness in the elderly.
    compre no iHERB.COM e use o codigo de desconto ABU346, compras acima de 40USD ganham 10% de desconto.. and help a brother out ;)

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  13. #7
    INICIANTE Avatar de CobradePrata
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    Padrão Re: Dose diaria de 25mg de CLOMID dobra os niveis de testosterona em homens

    excelente esse segundo...

    interessante o fato do cara com eixo lascado ter se recuperado com clomid...

    Só o preço dele que ainda meio salgado na farma :\.

  14. #8
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    Padrão Re: Dose diaria de 25mg de CLOMID dobra os niveis de testosterona em homens

    esse estudo("The effects of aging in normal men on bioavailable testosterone and luteinizing hormone secretion: response to clomiphene citrate, Bremner, William J, J Clin Endocrinol Metab. 1987 Dec;65(6):1118-26") esclareceu uma dúvida que tive logo ao começar a leitura; que era se essas terapias eram aplicáveis em homens com o eixo HTP estabilizado, mas, estou com outra:
    qual foi a dosagem utilizada durante essa semana?

  15. #9
    MENSHEALTH Avatar de tepan
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    Padrão Re: Dose diaria de 25mg de CLOMID dobra os niveis de testosterona em homens

    Ever so often, I get asked questions from doctors, and I figure that here is a reasonable place to put how I answer the frequently asked ones. As with everything I write, it’s my opinion, and doctors opinions vary.

    One question I get asked a lot is how to prescribe clomiphene for a male. Here’s how I do it.

    First, clomiphene works by stimulating the pituitary. If the pituitary’s already in overdrive, clomiphene won’t help. So if a man’s LH is high, like 25 IU/L, I don’t prescribe clomiphene.

    The next decision to make is what the target for therapy will be. If it’s augmenting a low testosterone level, then I’ll use the bioavailable testosterone calculation, As a reasonable threshold for total testosterone is 300 ng/dL and the portion of bioavailable testosterone ranges between 52% and 70%,1 I use the range between 156 ng/dL to 210 ng/dL as a lower limit of what is likely an adequate bioavailable testosterone level for a man. If the target for clomiphene therapy is stimulating the testis to make sperm, I use a higher threshold. If possible we try for twice as much, about 400 ng/dL for bioavailable and 600 ng/dl for total testosterone. It’s not always possible to achieve those levels.

    I start with 25 mg clomiphene a day. As the pills come in 50 mg, and the half-life is relatively long, patients can take a pill every other day. Some prefer talking half a 50 mg pill daily. After two weeks, I have the patient get tests for testosterone, LH, albumin, SHBG (sex hormone binding globulin) and estradiol. In some instances, the estradiol will increase, but as long as the ratio of total testosterone to estradiol is greater than ten-to-one, that shouldn’t be a problem. If the estradiol increases substantially, other therapy, like an aromatase inhibitor, is preferred. If thetestosterone is still low, then we’ll increase the clomiphene by 25 mg every other day or daily, and repeat the tests. I’ll increase the clomiphene to a maximum of 100 mg daily.

    I believe that clomiphene works better if a man’s testosterone is low. That’s a good indication that there is a problem that may be corrected. If the testosterone is reasonable at the start, 400 ng/dL or more, then pushing it higher may not be as effective. But that’s my opinion, and as of present, scientific studies don’t definitively prove it right or wrong.

    It’s important to note that clomiphene is “off-label” for use in the male.


    1S. Bhasin. Chapter 18: Testicular disorders. In: Kronenberg H. M., Melmed S., Polonsky K. S., and Reed Larsen P., eds. Williams Textbook of Endocrinology 11th ed. Philadelphia, W.B. Saunders Company, 2008; 647

    O tempo passa de duas formas, contra ou a favor. Se você está sempre treinando, o tempo é seu amigo, se você esta parado, o tempo se torna seu inimigo.

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